Veliparib Alone or in Combination with Mitomycin C in Patients with Solid Tumors With Functional Deficiency in Homologous Recombination Repair

BACKGROUND: BRCA germline mutations are being targeted for development of PARP inhibitors. BRCA genes collaborate with several others in the Fanconi Anemia (FA) pathway. We screened cancer patients’ tumors for FA functional defects then aimed to establish the safety/feasibility of administering PARP...

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Detalhes bibliográficos
Publicado no:J Natl Cancer Inst
Main Authors: Villalona-Calero, Miguel A., Duan, Wenrui, Zhao, Weiqiang, Shilo, Konstantin, Schaaf, Larry J., Thurmond, Jennifer, Westman, Judith A., Marshall, John, Xiaobai, Li, Ji, Jiuping, Rose, Jeffrey, Lustberg, Maryam, Bekaii-Saab, Tanios, Chen, Alice, Timmers, Cynthia
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4948564/
https://ncbi.nlm.nih.gov/pubmed/26848151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djv437
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