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Epigenetics and energetics in ventral hippocampus mediate rapid antidepressant action: Implications for treatment resistance

Although regulation of energy metabolism has been linked with multiple disorders, its role in depression and responsiveness to antidepressants is less known. We found that an epigenetic and energetic agent, acetyl-l-carnitine (LAC, oral administration), rapidly rescued the depressive- and central an...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Bigio, Benedetta, Mathé, Aleksander A., Sousa, Vasco C., Zelli, Danielle, Svenningsson, Per, McEwen, Bruce S., Nasca, Carla
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4948346/
https://ncbi.nlm.nih.gov/pubmed/27354525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1603111113
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