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Epigenetics and energetics in ventral hippocampus mediate rapid antidepressant action: Implications for treatment resistance

Although regulation of energy metabolism has been linked with multiple disorders, its role in depression and responsiveness to antidepressants is less known. We found that an epigenetic and energetic agent, acetyl-l-carnitine (LAC, oral administration), rapidly rescued the depressive- and central an...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Bigio, Benedetta, Mathé, Aleksander A., Sousa, Vasco C., Zelli, Danielle, Svenningsson, Per, McEwen, Bruce S., Nasca, Carla
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4948346/
https://ncbi.nlm.nih.gov/pubmed/27354525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1603111113
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