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Epigenetics and energetics in ventral hippocampus mediate rapid antidepressant action: Implications for treatment resistance

Although regulation of energy metabolism has been linked with multiple disorders, its role in depression and responsiveness to antidepressants is less known. We found that an epigenetic and energetic agent, acetyl-l-carnitine (LAC, oral administration), rapidly rescued the depressive- and central an...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Bigio, Benedetta, Mathé, Aleksander A., Sousa, Vasco C., Zelli, Danielle, Svenningsson, Per, McEwen, Bruce S., Nasca, Carla
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4948346/
https://ncbi.nlm.nih.gov/pubmed/27354525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1603111113
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