HAX1 deletion impairs BCR internalization and leads to delayed BCR-mediated apoptosis

Deletion of HAX1 in mice causes a severe reduction in the numbers of lymphocytes in the bone marrow and in the spleen. Additionally, B220(+) B progenitor cells in the bone marrow are reduced, suggesting an important function of HAX1 in B cell development. HAX1 is thought to play a protective role in...

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Bibliographische Detailangaben
Veröffentlicht in:Cell Mol Immunol
Hauptverfasser: Wolkerstorfer, Susanne, Schwaiger, Elisabeth, Rinnerthaler, Mark, Karina Gratz, Iris, Zoegg, Thomas, Brandstetter, Hans, Achatz-Straussberger, Gertrude
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4947813/
https://ncbi.nlm.nih.gov/pubmed/25864916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cmi.2015.18
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