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Structural investigation of heteroyohimbine alkaloid synthesis reveals active site elements that control stereoselectivity
Plants produce an enormous array of biologically active metabolites, often with stereochemical variations on the same molecular scaffold. These changes in stereochemistry dramatically impact biological activity. Notably, the stereoisomers of the heteroyohimbine alkaloids show diverse pharmacological...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4947188/ https://ncbi.nlm.nih.gov/pubmed/27418042 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12116 |
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