Structural investigation of heteroyohimbine alkaloid synthesis reveals active site elements that control stereoselectivity

Plants produce an enormous array of biologically active metabolites, often with stereochemical variations on the same molecular scaffold. These changes in stereochemistry dramatically impact biological activity. Notably, the stereoisomers of the heteroyohimbine alkaloids show diverse pharmacological...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Stavrinides, Anna, Tatsis, Evangelos C., Caputi, Lorenzo, Foureau, Emilien, Stevenson, Clare E. M., Lawson, David M., Courdavault, Vincent, O'Connor, Sarah E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4947188/
https://ncbi.nlm.nih.gov/pubmed/27418042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12116
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