Unlocking the Diversity of Alkaloids in Catharanthus roseus: Nuclear Localization Suggests Metabolic Channeling in Secondary Metabolism

The extraordinary chemical diversity of the plant-derived monoterpene indole alkaloids, which include vinblastine, quinine, and strychnine, originates from a single biosynthetic intermediate, strictosidine aglycone. Here we report for the first time the cloning of a biosynthetic gene and characteriz...

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Bibliographic Details
Published in:Chem Biol
Main Authors: Stavrinides, Anna, Tatsis, Evangelos C., Foureau, Emilien, Caputi, Lorenzo, Kellner, Franziska, Courdavault, Vincent, O’Connor, Sarah E.
Format: Artigo
Language:Inglês
Published: Elsevier 2015
Subjects:
Brief Communication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4372254/
https://ncbi.nlm.nih.gov/pubmed/25772467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2015.02.006
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