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Structural Basis of Cycloaddition in Biosynthesis of Iboga and Aspidosperma Alkaloids
Cycloaddition reactions generate chemical complexity in a single step. Here we report the crystal structures of three homologous plant-derived cyclases involved in the biosynthesis of iboga and aspidosperma alkaloids. These enzymes act on the same substrate, named angryline, to generate three distin...
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| izdano v: | Nat Chem Biol |
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| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2020
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7104359/ https://ncbi.nlm.nih.gov/pubmed/32066966 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-019-0460-x |
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