Solution of the multistep pathway for assembly of corynanthean, strychnos, iboga, and aspidosperma monoterpenoid indole alkaloids from 19E-geissoschizine

Monoterpenoid indole alkaloids (MIAs) possess a diversity of alkaloid skeletons whose biosynthesis is poorly understood. A bioinformatic search of candidate genes, combined with their virus-induced gene silencing, targeted MIA profiling and in vitro/in vivo pathway reconstitution identified and func...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Qu, Yang, Easson, Michael E. A. M., Simionescu, Razvan, Hajicek, Josef, Thamm, Antje M. K., Salim, Vonny, De Luca, Vincenzo
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2018
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5866588/
https://ncbi.nlm.nih.gov/pubmed/29511102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1719979115
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