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Mass spectrometry locates local and allosteric conformational changes that occur on cofactor binding
Fdc1 is a decarboxylase enzyme that requires the novel prenylated FMN cofactor for activity. Here, we use it as an exemplar system to show how native top-down and bottom-up mass spectrometry can measure the structural effect of cofactor binding by a protein. For Fdc1(Ubix), the cofactor confers stru...
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| Udgivet i: | Nat Commun |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4947166/ https://ncbi.nlm.nih.gov/pubmed/27418477 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12163 |
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