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Cryo-EM structure of aerolysin variants reveals a novel protein fold and the pore-formation process

Owing to their pathogenical role and unique ability to exist both as soluble proteins and transmembrane complexes, pore-forming toxins (PFTs) have been a focus of microbiologists and structural biologists for decades. PFTs are generally secreted as water-soluble monomers and subsequently bind the me...

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Dades bibliogràfiques
Publicat a:Nat Commun
Autors principals: Iacovache, Ioan, De Carlo, Sacha, Cirauqui, Nuria, Dal Peraro, Matteo, van der Goot, F. Gisou, Zuber, Benoît
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4947156/
https://ncbi.nlm.nih.gov/pubmed/27405240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12062
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