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A rivet model for channel formation by aerolysin-like pore-forming toxins
The bacterial toxin aerolysin kills cells by forming heptameric channels, of unknown structure, in the plasma membrane. Using disulfide trapping and cysteine scanning mutagenesis coupled to thiol-specific labeling on lipid bilayers, we identify a loop that lines the channel. This loop has an alterna...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1383540/ https://ncbi.nlm.nih.gov/pubmed/16424900 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600959 |
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