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A rivet model for channel formation by aerolysin-like pore-forming toxins

The bacterial toxin aerolysin kills cells by forming heptameric channels, of unknown structure, in the plasma membrane. Using disulfide trapping and cysteine scanning mutagenesis coupled to thiol-specific labeling on lipid bilayers, we identify a loop that lines the channel. This loop has an alterna...

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Detalhes bibliográficos
Main Authors: Iacovache, Ioan, Paumard, Patrick, Scheib, Holger, Lesieur, Claire, Sakai, Naomi, Matile, Stefan, Parker, Michael W, van der Goot, F Gisou
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1383540/
https://ncbi.nlm.nih.gov/pubmed/16424900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600959
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