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Heterogeneity in readouts of canonical Wnt pathway activity within intestinal crypts

BACKGROUND: Canonical Wnt pathway signaling is necessary for maintaining the proliferative capacity of mammalian intestinal crypt base columnar stem cells (CBCs). Further, dysregulation of the Wnt pathway is a major contributor to disease, including oncogenic transformation of the intestinal epithel...

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Détails bibliographiques
Publié dans:Dev Dyn
Auteurs principaux: Li, Ning, Yousefi, Maryam, Nakauka-Ddamba, Angela, Tobias, John W., Jensen, Shane T., Morrisey, Edward E., Lengner, Christopher J.
Format: Artigo
Langue:Inglês
Publié: 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4946997/
https://ncbi.nlm.nih.gov/pubmed/27264700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dvdy.24423
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