Cladribine and Fludarabine Nucleotides Induce Distinct Hexamers Defining a Common Mode of Reversible RNR Inhibition

The enzyme ribonucleotide reductase (RNR) is a major target of anticancer drugs. Until recently, suicide inactivation in which synthetic substrate analogs (nucleoside diphosphates) irreversibly inactivate the RNR-α(2)β(2) heterodimeric complex was the only clinically proven inhibition pathway. For i...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Wisitpitthaya, Somsinee, Zhao, Yi, Long, Marcus J. C., Li, Minxing, Fletcher, Elaine A., Blessing, William A., Weiss, Robert S., Aye, Yimon
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4946967/
https://ncbi.nlm.nih.gov/pubmed/27159113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00303
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