New Insight into the Catalytic Mechanism of Bacterial MraY from Enzyme Kinetics and Docking Studies

Phospho-MurNAc-pentapeptide translocase (MraY) catalyzes the synthesis of Lipid I, a bacterial peptidoglycan precursor. As such, MraY is essential for bacterial survival and therefore is an ideal target for developing novel antibiotics. However, the understanding of its catalytic mechanism, despite...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Rodrigues, João P. G. L. M., Bonvin, Alexandre M. J. J., Zaal, Esther A., Berkers, Celia R., Heger, Michal, Gawarecka, Katarzyna, Swiezewska, Ewa, Breukink, Eefjan, Egmond, Maarten R.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2016
Teme:
Enzymology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4946923/
https://ncbi.nlm.nih.gov/pubmed/27226570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.717884
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