Restoration of Mecp2 expression in GABAergic neurons is sufficient to rescue multiple disease features in a mouse model of Rett syndrome

The postnatal neurodevelopmental disorder Rett syndrome, caused by mutations in MECP2, produces a diverse array of symptoms, including loss of language, motor, and social skills and the development of hand stereotypies, anxiety, tremor, ataxia, respiratory dysrhythmias, and seizures. Surprisingly, d...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Ure, Kerstin, Lu, Hui, Wang, Wei, Ito-Ishida, Aya, Wu, Zhenyu, He, Ling-jie, Sztainberg, Yehezkel, Chen, Wu, Tang, Jianrong, Zoghbi, Huda Y
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4946897/
https://ncbi.nlm.nih.gov/pubmed/27328321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.14198
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