Loss and gain of MeCP2 lead to similar hippocampal circuit abnormalities that are rescued by deep brain stimulation in a Rett syndrome mouse model

Loss- and gain-of-function mutations in Methyl-CpG-binding protein 2 (MECP2) underlie two distinct neurological syndromes with strikingly similar features, but the synaptic and circuit-level changes mediating these shared features are undefined. Here we report three novel signs of neural circuit dys...

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Publicado no:Neuron
Main Authors: Lu, Hui, Ash, Ryan T., He, Lingjie, Kee, Sara E., Wang, Wei, Yu, Dinghui, Hao, Shuang, Meng, Xiangling, Ure, Kerstin, Ito-Ishida, Aya, Tang, Bin, Sun, Yaling, Ji, Daoyun, Tang, Jianrong, Arenkiel, Benjamin R., Smirnakis, Stelios M., Zoghbi, Huda Y.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5019177/
https://ncbi.nlm.nih.gov/pubmed/27499081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2016.07.018
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