Early-Life Social Isolation Stress Increases Kappa Opioid Receptor Responsiveness and Downregulates the Dopamine System

Chronic early-life stress increases vulnerability to alcoholism and anxiety disorders during adulthood. Similarly, rats reared in social isolation (SI) during adolescence exhibit augmented ethanol intake and anxiety-like behaviors compared with group housed (GH) rats. Prior studies suggest that disr...

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Vydáno v:Neuropsychopharmacology
Hlavní autoři: Karkhanis, Anushree N, Rose, Jamie H, Weiner, Jeffrey L, Jones, Sara R
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
Témata:
Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4946054/
https://ncbi.nlm.nih.gov/pubmed/26860203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2016.21
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