Supersensitive Kappa Opioid Receptors Promotes Ethanol Withdrawal-Related Behaviors and Reduce Dopamine Signaling in the Nucleus Accumbens

BACKGROUND: Chronic ethanol exposure reduces dopamine transmission in the nucleus accumbens, which may contribute to the negative affective symptoms associated with ethanol withdrawal. Kappa opioid receptors have been implicated in withdrawal-induced excessive drinking and anxiety-like behaviors and...

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Vydáno v:Int J Neuropsychopharmacol
Hlavní autoři: Rose, Jamie H., Karkhanis, Anushree N., Chen, Rong, Gioia, Dominic, Lopez, Marcelo F., Becker, Howard C., McCool, Brian A., Jones, Sara R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2015
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4886667/
https://ncbi.nlm.nih.gov/pubmed/26625893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ijnp/pyv127
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