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Synthesis of a Potent Vinblastine: Rationally Designed Added Benign Complexity
Many natural products, including vinblastine, have not been easily subjected to simplifications in their structures by synthetic means or modifications by late-stage semi-synthetic derivatization in ways that enhance their biological potency. Herein, we detail a synthetic vinblastine that incorporat...
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| Publicado no: | J Am Chem Soc |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4945418/ https://ncbi.nlm.nih.gov/pubmed/27356080 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b04330 |
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