Glutamine Metabolism Regulates the Pluripotency Transcription Factor OCT4

The molecular mechanisms underlying the regulation of pluripotency by cellular metabolism in human embryonic stem cells (hESCs) are not fully understood. We found that high levels of glutamine metabolism are essential to prevent degradation of OCT4, a key transcription factor regulating hESC pluripo...

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發表在:Cell Rep
Main Authors: Marsboom, Glenn, Zhang, Guo-Fang, Pohl-Avila, Nicole, Zhang, Yanmin, Yuan, Yang, Kang, Hojin, Hao, Bo, Brunengraber, Henri, Malik, Asrar B., Rehman, Jalees
格式: Artigo
語言:Inglês
出版: 2016
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4945388/
https://ncbi.nlm.nih.gov/pubmed/27346346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.05.089
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