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Glutamine Metabolism Regulates the Pluripotency Transcription Factor OCT4
The molecular mechanisms underlying the regulation of pluripotency by cellular metabolism in human embryonic stem cells (hESCs) are not fully understood. We found that high levels of glutamine metabolism are essential to prevent degradation of OCT4, a key transcription factor regulating hESC pluripo...
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| Publicado no: | Cell Rep |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4945388/ https://ncbi.nlm.nih.gov/pubmed/27346346 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.05.089 |
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