Glutamine Metabolism Regulates the Pluripotency Transcription Factor OCT4

The molecular mechanisms underlying the regulation of pluripotency by cellular metabolism in human embryonic stem cells (hESCs) are not fully understood. We found that high levels of glutamine metabolism are essential to prevent degradation of OCT4, a key transcription factor regulating hESC pluripo...

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Bibliografiske detaljer
Udgivet i:Cell Rep
Main Authors: Marsboom, Glenn, Zhang, Guo-Fang, Pohl-Avila, Nicole, Zhang, Yanmin, Yuan, Yang, Kang, Hojin, Hao, Bo, Brunengraber, Henri, Malik, Asrar B., Rehman, Jalees
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4945388/
https://ncbi.nlm.nih.gov/pubmed/27346346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.05.089
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