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Dual control by Cdk1 phosphorylation of the budding yeast APC/C ubiquitin ligase activator Cdh1

The antagonism between cyclin-dependent kinases (Cdks) and the ubiquitin ligase APC/C-Cdh1 is central to eukaryotic cell cycle control. APC/C-Cdh1 targets cyclin B and other regulatory proteins for degradation, whereas Cdks disable APC/C-Cdh1 through phosphorylation of the Cdh1 activator protein at...

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發表在:Mol Biol Cell
Main Authors: Höckner, Sebastian, Neumann-Arnold, Lea, Seufert, Wolfgang
格式: Artigo
語言:Inglês
出版: The American Society for Cell Biology 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4945139/
https://ncbi.nlm.nih.gov/pubmed/27226481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E15-11-0787
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