A Cytolethal Distending Toxin Variant from Aggregatibacter actinomycetemcomitans with an Aberrant CdtB That Lacks the Conserved Catalytic Histidine 160

The periodontopathogen Aggregatibacter actinomycetemcomitans synthesizes several virulence factors, including cytolethal distending toxin (CDT). The active CDT holoenzyme is an AB-type tripartite genotoxin that affects eukaryotic cells. Subunits CdtA and CdtC (B-components) allow binding and intrace...

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Publicat a:PLoS One
Autors principals: Obradović, Davor, Gašperšič, Rok, Caserman, Simon, Leonardi, Adrijana, Jamnik, Maja, Podlesek, Zdravko, Seme, Katja, Anderluh, Gregor, Križaj, Igor, Maček, Peter, Butala, Matej
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4945079/
https://ncbi.nlm.nih.gov/pubmed/27414641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0159231
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