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Measurements of Intrahost Viral Diversity Are Extremely Sensitive to Systematic Errors in Variant Calling
With next-generation sequencing technologies, it is now feasible to efficiently sequence patient-derived virus populations at a depth of coverage sufficient to detect rare variants. However, each sequencing platform has characteristic error profiles, and sample collection, target amplification, and...
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| 發表在: | J Virol |
|---|---|
| Main Authors: | , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Microbiology
2016
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4944299/ https://ncbi.nlm.nih.gov/pubmed/27194763 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00667-16 |
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