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Measurements of Intrahost Viral Diversity Are Extremely Sensitive to Systematic Errors in Variant Calling

With next-generation sequencing technologies, it is now feasible to efficiently sequence patient-derived virus populations at a depth of coverage sufficient to detect rare variants. However, each sequencing platform has characteristic error profiles, and sample collection, target amplification, and...

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Podrobná bibliografie
Vydáno v:J Virol
Hlavní autoři: McCrone, John T., Lauring, Adam S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4944299/
https://ncbi.nlm.nih.gov/pubmed/27194763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00667-16
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