Targeted Mutagenesis of Guinea Pig Cytomegalovirus Using CRISPR/Cas9-Mediated Gene Editing

The cytomegaloviruses (CMVs) are among the most genetically complex mammalian viruses, with viral genomes that often exceed 230 kbp. Manipulation of cytomegalovirus genomes is largely performed using infectious bacterial artificial chromosomes (BACs), which necessitates the maintenance of the viral...

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Bibliografske podrobnosti
izdano v:J Virol
Main Authors: Bierle, Craig J., Anderholm, Kaitlyn M., Wang, Jian Ben, McVoy, Michael A., Schleiss, Mark R.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2016
Teme:
Genome Replication and Regulation of Viral Gene Expression
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4944286/
https://ncbi.nlm.nih.gov/pubmed/27226370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00139-16
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