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Targeted Mutagenesis of Guinea Pig Cytomegalovirus Using CRISPR/Cas9-Mediated Gene Editing

The cytomegaloviruses (CMVs) are among the most genetically complex mammalian viruses, with viral genomes that often exceed 230 kbp. Manipulation of cytomegalovirus genomes is largely performed using infectious bacterial artificial chromosomes (BACs), which necessitates the maintenance of the viral...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Bierle, Craig J., Anderholm, Kaitlyn M., Wang, Jian Ben, McVoy, Michael A., Schleiss, Mark R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4944286/
https://ncbi.nlm.nih.gov/pubmed/27226370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00139-16
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