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Targeted Mutagenesis of Guinea Pig Cytomegalovirus Using CRISPR/Cas9-Mediated Gene Editing

The cytomegaloviruses (CMVs) are among the most genetically complex mammalian viruses, with viral genomes that often exceed 230 kbp. Manipulation of cytomegalovirus genomes is largely performed using infectious bacterial artificial chromosomes (BACs), which necessitates the maintenance of the viral...

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Foilsithe in:J Virol
Main Authors: Bierle, Craig J., Anderholm, Kaitlyn M., Wang, Jian Ben, McVoy, Michael A., Schleiss, Mark R.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2016
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4944286/
https://ncbi.nlm.nih.gov/pubmed/27226370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00139-16
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