Targeted Mutagenesis of Guinea Pig Cytomegalovirus Using CRISPR/Cas9-Mediated Gene Editing

The cytomegaloviruses (CMVs) are among the most genetically complex mammalian viruses, with viral genomes that often exceed 230 kbp. Manipulation of cytomegalovirus genomes is largely performed using infectious bacterial artificial chromosomes (BACs), which necessitates the maintenance of the viral...

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Dettagli Bibliografici
Pubblicato in:J Virol
Autori principali: Bierle, Craig J., Anderholm, Kaitlyn M., Wang, Jian Ben, McVoy, Michael A., Schleiss, Mark R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2016
Soggetti:
Genome Replication and Regulation of Viral Gene Expression
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4944286/
https://ncbi.nlm.nih.gov/pubmed/27226370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00139-16
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