Complex effects of inhibiting hepatic apolipoprotein B100 synthesis in humans

Mipomersen is a 20mer antisense oligonucleotide (ASO) that inhibits apolipoprotein B (apoB) synthesis; its low-density lipoprotein (LDL)–lowering effects should therefore result from reduced secretion of very-low-density lipoprotein (VLDL). We enrolled 17 healthy volunteers who received placebo inje...

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Foilsithe in:Sci Transl Med
Main Authors: Reyes-Soffer, Gissette, Moon, Byoung, Hernandez-Ono, Antonio, Dionizovik-Dimanovski, Marija, Jimenez, Jhonsua, Obunike, Joseph, Thomas, Tiffany, Ngai, Colleen, Fontanez, Nelson, Donovan, Daniel S., Karmally, Wahida, Holleran, Stephen, Ramakrishnan, Rajasekhar, Mittleman, Robert S., Ginsberg, Henry N.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2016
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4944115/
https://ncbi.nlm.nih.gov/pubmed/26819195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aad2195
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