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Effects of APOC3 Heterozygous Deficiency on Plasma Lipid and Lipoprotein Metabolism
OBJECTIVE: Apolipoprotein (apo)CIII inhibits lipoprotein lipase (LpL)-mediated lipolysis of very low density lipoprotein (VLDL) TG and decreases hepatic uptake of VLDL remnants. The discovery that 5% of Lancaster Old Order Amish are heterozygous for the APOC3 R19X null mutation provided the opportun...
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| Publicado no: | Arterioscler Thromb Vasc Biol |
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| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6309928/ https://ncbi.nlm.nih.gov/pubmed/30580564 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.118.311476 |
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