Effects of APOC3 Heterozygous Deficiency on Plasma Lipid and Lipoprotein Metabolism

OBJECTIVE: Apolipoprotein (apo)CIII inhibits lipoprotein lipase (LpL)-mediated lipolysis of very low density lipoprotein (VLDL) TG and decreases hepatic uptake of VLDL remnants. The discovery that 5% of Lancaster Old Order Amish are heterozygous for the APOC3 R19X null mutation provided the opportun...

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Publicado no:Arterioscler Thromb Vasc Biol
Main Authors: Reyes-Soffer, Gissette, Sztalryd, Carol, Horenstein, Richard B., Holleran, Stephen, Matveyenko, Anastasiya, Thomas, Tiffany, Nandakumar, Renu, Ngai, Colleen, Karmally, Wahida, Ginsberg, Henry N, Ramakrishnan, Rajasekhar, Pollin, Toni I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6309928/
https://ncbi.nlm.nih.gov/pubmed/30580564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.118.311476
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