A Missense Mutation of the Gene Encoding Synaptic Vesicle Glycoprotein 2A (SV2A) Confers Seizure Susceptibility by Disrupting Amygdalar Synaptic GABA Release

Synaptic vesicle glycoprotein 2A (SV2A) is specifically expressed in the membranes of synaptic vesicles and modulates action potential-dependent neurotransmitter release. To explore the role of SV2A in the pathogenesis of epileptic disorders, we recently generated a novel rat model (Sv2a(L174Q) rat)...

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Bibliographische Detailangaben
Veröffentlicht in:Front Pharmacol
Hauptverfasser: Tokudome, Kentaro, Okumura, Takahiro, Terada, Ryo, Shimizu, Saki, Kunisawa, Naofumi, Mashimo, Tomoji, Serikawa, Tadao, Sasa, Masashi, Ohno, Yukihiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2016
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4943941/
https://ncbi.nlm.nih.gov/pubmed/27471467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2016.00210
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