A Missense Mutation of the Gene Encoding Synaptic Vesicle Glycoprotein 2A (SV2A) Confers Seizure Susceptibility by Disrupting Amygdalar Synaptic GABA Release

Synaptic vesicle glycoprotein 2A (SV2A) is specifically expressed in the membranes of synaptic vesicles and modulates action potential-dependent neurotransmitter release. To explore the role of SV2A in the pathogenesis of epileptic disorders, we recently generated a novel rat model (Sv2a(L174Q) rat)...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Front Pharmacol
Autores principales: Tokudome, Kentaro, Okumura, Takahiro, Terada, Ryo, Shimizu, Saki, Kunisawa, Naofumi, Mashimo, Tomoji, Serikawa, Tadao, Sasa, Masashi, Ohno, Yukihiro
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2016
Materias:
Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4943941/
https://ncbi.nlm.nih.gov/pubmed/27471467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2016.00210
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares