A Missense Mutation of the Gene Encoding Synaptic Vesicle Glycoprotein 2A (SV2A) Confers Seizure Susceptibility by Disrupting Amygdalar Synaptic GABA Release

Synaptic vesicle glycoprotein 2A (SV2A) is specifically expressed in the membranes of synaptic vesicles and modulates action potential-dependent neurotransmitter release. To explore the role of SV2A in the pathogenesis of epileptic disorders, we recently generated a novel rat model (Sv2a(L174Q) rat)...

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Detalles Bibliográficos
Publicado en:Front Pharmacol
Main Authors: Tokudome, Kentaro, Okumura, Takahiro, Terada, Ryo, Shimizu, Saki, Kunisawa, Naofumi, Mashimo, Tomoji, Serikawa, Tadao, Sasa, Masashi, Ohno, Yukihiro
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2016
Assuntos:
Pharmacology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4943941/
https://ncbi.nlm.nih.gov/pubmed/27471467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2016.00210
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