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An APC/C-Cdh1 Biosensor Reveals the Dynamics of Cdh1 Inactivation at the G1/S Transition

B-type cyclin-dependent kinase activity must be turned off for mitotic exit and G1 stabilization. B-type cyclin degradation is mediated by the anaphase-promoting complex/cyclosome (APC/C); during and after mitotic exit, APC/C is dependent on Cdh1. Cdh1 is in turn phosphorylated and inactivated by cy...

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Foilsithe in:PLoS One
Main Authors: Ondracka, Andrej, Robbins, Jonathan A., Cross, Frederick R.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2016
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4943722/
https://ncbi.nlm.nih.gov/pubmed/27410035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0159166
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