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The emerging role of APC/C(Cdh1) in controlling differentiation, genomic stability and tumor suppression

Deregulation of the G1/G0 phase of the cell cycle can lead to cancer. During G1, most cells commit alternatively to DNA replication and division, or to cell cycle exit and differentiation. The anaphase-promoting complex or cyclosome (APC/C) activated by Cdh1 coordinately eliminates positive cell cyc...

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Detalhes bibliográficos
Main Authors: Wäsch, Ralph, Robbins, Jonathan A., Cross, Frederick R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3102600/
https://ncbi.nlm.nih.gov/pubmed/19826416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.325
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