Resolving Discrepant Findings on ANGPTL8 in β-Cell Proliferation: A Collaborative Approach to Resolving the Betatrophin Controversy

The β-cell mitogenic effects of ANGPTL8 have been subjected to substantial debate. The original findings suggested that ANGPTL8 overexpression in mice induced a 17-fold increase in β-cell proliferation. Subsequent studies in mice contested this claim, but a more recent report in rats supported the o...

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Publicat a:PLoS One
Autors principals: Cox, Aaron R., Barrandon, Ornella, Cai, Erica P., Rios, Jacqueline S., Chavez, Julia, Bonnyman, Claire W., Lam, Carol J., Yi, Peng, Melton, Douglas A., Kushner, Jake A.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4943640/
https://ncbi.nlm.nih.gov/pubmed/27410263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0159276
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