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Founder and Recurrent Mutations in BRCA1 and BRCA2 Genes in Latin American Countries: State of the Art and Literature Review

BACKGROUND. Numerous epidemiological factors affect the probability of developing breast or ovarian cancer, but no predictor is as determinant as inheriting a mutation in BRCA1 or BRCA2. The concept of the founder effect explains the reduced genetic variability in some populations, according to the...

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Detalhes bibliográficos
Publicado no:Oncologist
Main Authors: Ossa, Carlos Andrés, Torres, Diana
Formato: Artigo
Idioma:Inglês
Publicado em: AlphaMed Press 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4943386/
https://ncbi.nlm.nih.gov/pubmed/27286788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2015-0416
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