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Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis
The intestinal mucosal barrier controlling the resident microbiome is dependent on a protective mucus layer generated by goblet cells, impairment of which is a hallmark of the inflammatory bowel disease Ulcerative Colitis. Here we show that IL-18 is critical in driving the pathologic breakdown of ba...
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| Publicado no: | Cell |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4943028/ https://ncbi.nlm.nih.gov/pubmed/26638073 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.10.072 |
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