Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis

The intestinal mucosal barrier controlling the resident microbiome is dependent on a protective mucus layer generated by goblet cells, impairment of which is a hallmark of the inflammatory bowel disease Ulcerative Colitis. Here we show that IL-18 is critical in driving the pathologic breakdown of ba...

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Publicado en:Cell
Autores principales: Nowarski, Roni, Jackson, Ruaidhrí, Gagliani, Nicola, de Zoete, Marcel R., Palm, Noah W., Bailis, Will, Low, Jun Siong, Harman, Christian C.D., Graham, Morven, Elinav, Eran, Flavell, Richard A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4943028/
https://ncbi.nlm.nih.gov/pubmed/26638073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.10.072
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