Rotavirus acceleration of type 1 diabetes in non-obese diabetic mice depends on type I interferon signalling

Rotavirus infection is associated with childhood progression to type 1 diabetes. Infection by monkey rotavirus RRV accelerates diabetes onset in non-obese diabetic (NOD) mice, which relates to regional lymph node infection and a T helper 1-specific immune response. When stimulated ex vivo with RRV,...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Pane, Jessica A., Fleming, Fiona E., Graham, Kate L., Thomas, Helen E., Kay, Thomas W. H., Coulson, Barbara S.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4942798/
https://ncbi.nlm.nih.gov/pubmed/27405244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep29697
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