Monitoring G protein-coupled receptor and β-arrestin trafficking in live cells using enhanced bystander BRET

Endocytosis and intracellular trafficking of receptors are pivotal to maintain physiological functions and drug action; however, robust quantitative approaches are lacking to study such processes in live cells. Here we present new bioluminescence resonance energy transfer (BRET) sensors to quantitat...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Namkung, Yoon, Le Gouill, Christian, Lukashova, Viktoria, Kobayashi, Hiroyuki, Hogue, Mireille, Khoury, Etienne, Song, Mideum, Bouvier, Michel, Laporte, Stéphane A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4942582/
https://ncbi.nlm.nih.gov/pubmed/27397672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12178
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