Hydrodynamic Radii of Ranibizumab, Aflibercept and Bevacizumab Measured by Time-Resolved Phosphorescence Anisotropy

PURPOSE: To measure the hydrodynamic radii of intravitreal anti-VEGF drugs ranibizumab, aflibercept and bevacizumab with μs time-resolved phosphorescence anisotropy. METHODS: Ruthenium-based dye Ru(bpy)(2)(mcbpy − O − Su − ester)(PF(6))(2), whose lifetime of several hundred nanoseconds is comparable...

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Bibliografische gegevens
Gepubliceerd in:Pharm Res
Hoofdauteurs: Hirvonen, Liisa M., Fruhwirth, Gilbert O., Srikantha, Nishanthan, Barber, Matthew J., Neffendorf, James E., Suhling, Klaus, Jackson, Timothy L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Springer US 2016
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Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4942501/
https://ncbi.nlm.nih.gov/pubmed/27225494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-016-1940-2
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