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Formulation Stabilization and Disaggregation of Bevacizumab, Ranibizumab and Aflibercept in Dilute Solutions

PURPOSE: Studies were conducted to investigate dilute solutions of the monoclonal antibody (mAb) bevacizumab, mAb fragment ranibizumab and fusion protein aflibercept, develop common procedures for formulation of low concentration mAbs and identify a stabilizing formulation for anti-VEGF mAbs for use...

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Dades bibliogràfiques
Publicat a:Pharm Res
Autors principals: Giannos, Steven A., Kraft, Edward R., Zhao, Zhen-Yang, Merkley, Kevin H., Cai, Jiyang
Format: Artigo
Idioma:Inglês
Publicat: Springer US 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5830485/
https://ncbi.nlm.nih.gov/pubmed/29492680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-018-2368-7
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