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Copper-induced structural conversion templates prion protein oligomerization and neurotoxicity
Prion protein (PrP) misfolding and oligomerization are key pathogenic events in prion disease. Copper exposure has been linked to prion pathogenesis; however, its mechanistic basis is unknown. We resolve, with single-molecule precision, the molecular mechanism of Cu(2+)-induced misfolding of PrP und...
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| Publicado no: | Sci Adv |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Association for the Advancement of Science
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4942324/ https://ncbi.nlm.nih.gov/pubmed/27419232 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1600014 |
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