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Cu,Zn–Superoxide Dismutase–Mediated Redox Regulation of Jumonji Domain Containing 3 Modulates Macrophage Polarization and Pulmonary Fibrosis
M2 macrophages are implicated in the development of pulmonary fibrosis as they generate profibrotic signals. The polarization process, at least in part, is regulated by epigenetic modulation. Because Cu,Zn–superoxide dismutase–induced H(2)O(2) can polarize macrophages to a profibrotic M2 phenotype,...
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| Veröffentlicht in: | Am J Respir Cell Mol Biol |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Thoracic Society
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4942206/ https://ncbi.nlm.nih.gov/pubmed/26699812 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2015-0183OC |
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