Glucocorticoids Alter CRTC-CREB Signaling in Muscle Cells: Impact on PGC-1α Expression and Atrophy Markers

Muscle wasting associated with chronic diseases has been linked to decreased expression of PGC-1α and overexpression of PGC-1α counters muscle loss. CREB, in conjunction with the CREB-regulated transcription coactivator (CRTC2), is a positive modulator of PGC-1α transcription. We previously reported...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Rahnert, Jill A., Zheng, Bin, Hudson, Matthew B., Woodworth-Hobbs, Myra E., Price, S. Russ
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2016
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4942104/
https://ncbi.nlm.nih.gov/pubmed/27404111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0159181
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