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Common Internal Allosteric Network Links Anesthetic Binding Sites in a Pentameric Ligand-Gated Ion Channel

General anesthetics bind reversibly to ion channels, modifying their global conformational distributions, but the underlying atomic mechanisms are not completely known. We examine this issue by way of the model protein Gloeobacter violaceous ligand-gated ion channel (GLIC) using computational molecu...

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Publicat a:PLoS One
Autors principals: Joseph, Thomas T., Mincer, Joshua S.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4942068/
https://ncbi.nlm.nih.gov/pubmed/27403526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0158795
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