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Targeting the AAA ATPase p97 as an approach to treat cancer through disruption of protein homeostasis
p97 is a AAA-ATPase with multiple cellular functions, one of which is critical regulation of protein homeostasis pathways. We describe the characterization of CB-5083, a potent, selective and orally bioavailable inhibitor of p97. Treatment of tumor cells with CB-5083 leads to accumulation of poly-ub...
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Publicado no: | Cancer Cell |
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Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2015
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4941640/ https://ncbi.nlm.nih.gov/pubmed/26555175 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2015.10.002 |
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