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Directly measuring single-molecule heterogeneity using force spectroscopy

One of the most intriguing results of single-molecule experiments on proteins and nucleic acids is the discovery of functional heterogeneity: the observation that complex cellular machines exhibit multiple, biologically active conformations. The structural differences between these conformations may...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Hinczewski, Michael, Hyeon, Changbong, Thirumalai, D.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2016
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Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4941464/
https://ncbi.nlm.nih.gov/pubmed/27317744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1518389113
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