Development of a specific affinity-matured exosite inhibitor to MT1-MMP that efficiently inhibits tumor cell invasion in vitro and metastasis in vivo

The membrane-associated matrix metalloproteinase-14, MT1-MMP, has been implicated in pericellular proteolysis with an important role in cellular invasion of collagenous tissues. It is substantially upregulated in various cancers and rheumatoid arthritis, and has been considered as a potential therap...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Botkjaer, Kenneth A., Kwok, Hang Fai, Terp, Mikkel G., Karatt-Vellatt, Aneesh, Santamaria, Salvatore, McCafferty, John, Andreasen, Peter A., Itoh, Yoshifumi, Ditzel, Henrik J., Murphy, Gillian
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4941350/
https://ncbi.nlm.nih.gov/pubmed/26934448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7780
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