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Probing the Twisted Structure of Sickle Hemoglobin Fibers via Particle Simulations
Polymerization of sickle hemoglobin (HbS) is the primary pathogenic event of sickle cell disease. For insight into the nature of the HbS polymer fiber formation, we develop a particle model—resembling a coarse-grained molecular model—constructed to match the intermolecular contacts between HbS molec...
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| Published in: | Biophys J |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
The Biophysical Society
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4940994/ https://ncbi.nlm.nih.gov/pubmed/27166816 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.04.002 |
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