Distinct gene regulatory programs define the inhibitory effects of liver X receptors and PPARG on cancer cell proliferation

BACKGROUND: The liver X receptors (LXRs, NR1H2 and NR1H3) and peroxisome proliferator-activated receptor gamma (PPARG, NR1C3) nuclear receptor transcription factors (TFs) are master regulators of energy homeostasis. Intriguingly, recent studies suggest that these metabolic regulators also impact tum...

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Bibliografiska uppgifter
I publikationen:Genome Med
Huvudupphovsmän: Savic, Daniel, Ramaker, Ryne C., Roberts, Brian S., Dean, Emma C., Burwell, Todd C., Meadows, Sarah K., Cooper, Sara J., Garabedian, Michael J., Gertz, Jason, Myers, Richard M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2016
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4940857/
https://ncbi.nlm.nih.gov/pubmed/27401066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-016-0328-6
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